RAP2A and RAPGEF5

Number of citations of the paper that reports this interaction (PubMedID 10777494)
110

Data Source:
HPRD (in vitro)

		RAP2A	RAPGEF5
Description		RAP2A, member of RAS oncogene family	Rap guanine nucleotide exchange factor 5
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Small GTPase Mediated Signal Transduction Nervous System Development
Pathways
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292)
Interacting Genes		31 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		5911	9771
HPRD ID		01547	15208
Ensembl ID		ENSG00000125249	ENSG00000136237
Uniprot IDs		P10114	A8MQ07 Q5JPD2 Q92565
PDB IDs		1KAO 2RAP 3RAP	1WGY
Enriched GO Terms of Interacting Partners?
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