RAP2A and RAPGEF3

Number of citations of the paper that reports this interaction (PubMedID 10777494)
110

Data Source:
BioGRID (enzymatic study)

		RAP2A	RAPGEF3
Description		RAP2A, member of RAS oncogene family	Rap guanine nucleotide exchange factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Domain Specific Binding CAMP Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Angiogenesis Signal Transduction CAMP-mediated Signaling Rap Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP Positive Regulation Of Protein Acetylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Histone H3-K9 Acetylation
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		31 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	7 interacting genes: AP2B1 DAPK1 MAP1A PNMA1 RAP1A RAP2A RRAS2
Entrez ID		5911	10411
HPRD ID		01547	06928
Ensembl ID		ENSG00000125249	ENSG00000079337
Uniprot IDs		P10114	O95398 Q99777
PDB IDs		1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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