HAMP and SLC40A1

Number of citations of the paper that reports this interaction (PubMedID 15514116)
1140

Data Source:
HPRD (in vivo)

		HAMP	SLC40A1
Description		hepcidin antimicrobial peptide	solute carrier family 40 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Intercalated Disc Apical Cortex	Cell Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Hormone Activity	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Signal Transduction Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Response To Ethanol Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation	Lymphocyte Homeostasis Endothelium Development Cellular Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Spleen Trabecula Formation Multicellular Organismal Iron Ion Homeostasis Divalent Inorganic Cation Transport Ferrous Iron Export Across Plasma Membrane
Pathways			Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Irritable bowel syndrome ( 29673008) Red cell distribution width ( 28957414)	Bone fracture in osteoporosis ( 28580392) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		5 interacting genes: CKAP4 EXOSC5 GLP1R SLC40A1 VKORC1	2 interacting genes: GOLM1 HAMP
Entrez ID		57817	30061
HPRD ID		05925	05229
Ensembl ID		ENSG00000105697	ENSG00000138449
Uniprot IDs		P81172	Q9NP59
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE
Enriched GO Terms of Interacting Partners?
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