SLC40A1

Description		solute carrier family 40 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding
	Biological Process	Lymphocyte Homeostasis Endothelium Development Cellular Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Spleen Trabecula Formation Multicellular Organismal Iron Ion Homeostasis Divalent Inorganic Cation Transport Ferrous Iron Export Across Plasma Membrane
Pathways		Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Bone fracture in osteoporosis ( 28580392) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		2 interacting genes: GOLM1 HAMP
Entrez ID		30061
HPRD ID		05229
Ensembl ID		ENSG00000138449
Uniprot IDs		Q9NP59
PDB IDs
Enriched GO Terms of Interacting Partners?
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