SUN2 and ALS2

		SUN2	ALS2
Description		Sad1 and UNC84 domain containing 2	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Condensed Nuclear Chromosome Cell Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Ruffle Nucleus Early Endosome Centrosome Cytosol Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Neuronal Cell Body Dendritic Spine
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein Membrane Anchor	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding
	Biological Process	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane	Behavioral Fear Response In Utero Embryonic Development Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Axonogenesis Neuromuscular Junction Development Locomotory Behavior Protein Localization Cell Death Endosomal Transport Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Meiotic synapsis	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		14 interacting genes: ALS2 APOBEC3C HGS MAFF MUC16 NRM PAEP PSMC2 RAB5B RASD2 RGS2 RPS20 SH3BP1 TXN2	4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB
Entrez ID		25777	57679
HPRD ID		15611	05893
Ensembl ID		ENSG00000100242	ENSG00000003393
Uniprot IDs		A0A024R1P7 B4E2A6 Q9UH99	A8K4R4 Q96Q42
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?
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