RHOJ and DOCK8

Number of citations of the paper that reports this interaction (PubMedID 15304341)
33

Data Source:
HPRD (two hybrid)

		RHOJ	DOCK8
Description		ras homolog family member J	dedicator of cytokinesis 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Angiogenesis Endocytosis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration
Pathways		Rho GTPase cycle	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1 ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		20 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 MEOX2 PAK1 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL	24 interacting genes: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		57381	81704
HPRD ID		09632	10920
Ensembl ID		ENSG00000126785	ENSG00000107099
Uniprot IDs		A0A024R692 Q7Z513 Q9H4E5	E2J6M5 E2J6M6 Q8NF50
PDB IDs
Enriched GO Terms of Interacting Partners?
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