THAP11 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid)

		THAP11	ECT2
Description		THAP domain containing 11	epithelial cell transforming 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytosol Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)	Obesity-related traits ( 23251661)
Interacting Genes		18 interacting genes: C9orf16 CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 HEMGN LRRC45 MCPH1 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52	37 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		57215	1894
HPRD ID		11629	11860
Ensembl ID		ENSG00000168286	ENSG00000114346
Uniprot IDs		Q96EK4	Q9H8V3
PDB IDs		2LAU 5AJS	3L46 4N40
Enriched GO Terms of Interacting Partners?
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