PELI2 and THAP7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PELI2	THAP7
Description		pellino E3 ubiquitin protein ligase family member 2	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nuclear Chromatin Nucleoplasm Nuclear Speck Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		19 interacting genes: BCL10 CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 TIMM9 TP53 UBQLN4	35 interacting genes: APP CCDC85B CCNDBP1 EHMT2 FBXO7 GNAI1 GOLGA2 H3C1 H4C1 HCFC1 HDAC3 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 LNX1 LURAP1 LZTS2 MAP1LC3B MDFI MID2 MTUS2 NOTCH2NLA PELI2 PHC2 PIN1 PPP3CC SET TAF1B TFIP11 THAP11 TRAF1 TRAF2 ZDHHC17
Entrez ID		57161	80764
HPRD ID		17835	15500
Ensembl ID		ENSG00000139946	ENSG00000184436
Uniprot IDs		Q9H716 Q9HAT8	Q9BT49
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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