PELI2 and DEAF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PELI2	DEAF1
Description		pellino E3 ubiquitin protein ligase family member 2	DEAF1 transcription factor
Image
GO Annotations	Cellular Component	Cytosol	Nuclear Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Germ Cell Development Visual Learning Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		19 interacting genes: BCL10 CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 TIMM9 TP53 UBQLN4	19 interacting genes: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A FHL1 GOLGA3 GSK3A GSK3B HRAS INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B RIDA TK1
Entrez ID		57161	10522
HPRD ID		17835	04027
Ensembl ID		ENSG00000139946	ENSG00000177030
Uniprot IDs		Q9H716 Q9HAT8	O75398
PDB IDs		3EGA 3EGB	2JW6 4A24 5UWW
Enriched GO Terms of Interacting Partners?
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