THAP7 and TAF1B

Number of citations of the paper that reports this interaction (PubMedID 15561719)
30

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		THAP7	TAF1B
Description		THAP domain containing 7	TATA-box binding protein associated factor, RNA polymerase I subunit B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Nuclear Speck Nuclear Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus RNA Polymerase I Core Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase I CORE Element Sequence-specific DNA Binding Protein Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	RNA Polymerase I Preinitiation Complex Assembly Transcription, DNA-templated Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic
Pathways			SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Egg allergy (maternal genetic effects) ( 29489655) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Nonsyndromic cleft lip with cleft palate ( 28232668) Prostate cancer ( 23535732)
Interacting Genes		35 interacting genes: APP CCDC85B CCNDBP1 EHMT2 FBXO7 GNAI1 GOLGA2 H3C1 H4C1 HCFC1 HDAC3 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 LNX1 LURAP1 LZTS2 MAP1LC3B MDFI MID2 MTUS2 NOTCH2NLA PELI2 PHC2 PIN1 PPP3CC SET TAF1B TFIP11 THAP11 TRAF1 TRAF2 ZDHHC17	24 interacting genes: APP EP300 ESR1 H2AC20 H2BC21 H3C1 H4C1 MYC NAPB NEDD4 NEDD4L PGR RRN3 RXRA SRPK1 TAF1A TAF1C TAF1D TBP THAP7 TP53 TRB TRIM24 UBTF
Entrez ID		80764	9014
HPRD ID		15500	05363
Ensembl ID		ENSG00000184436	ENSG00000115750
Uniprot IDs		Q9BT49	Q53T94
PDB IDs
Enriched GO Terms of Interacting Partners?
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