PELI2 and CREB3L3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PELI2	CREB3L3
Description		pellino E3 ubiquitin protein ligase family member 2	cAMP responsive element binding protein 3 like 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding CAMP Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		19 interacting genes: BCL10 CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 TIMM9 TP53 UBQLN4	12 interacting genes: ATF6 BAD CEBPG CREB3 CREB3L1 CSNK2A1 GSK3B KHDRBS1 KPNA2 PELI2 RIOK3 USP7
Entrez ID		57161	84699
HPRD ID		17835	16752
Ensembl ID		ENSG00000139946	ENSG00000060566
Uniprot IDs		Q9H716 Q9HAT8	Q68CJ9
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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