EIF4ENIF1 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, pull down)

		EIF4ENIF1	DDX6
Description		eukaryotic translation initiation factor 4E nuclear import factor 1	DEAD-box helicase 6
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Intracellular Membrane-bounded Organelle	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Nuclear Export	Viral RNA Genome Packaging Stem Cell Population Maintenance Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		Age-related hearing impairment ( 24939585)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)
Interacting Genes		21 interacting genes: ATXN1 CDK6 DDX6 DEF6 DTX2 EFHC1 EIF3E EIF4E EIF4E2 FANCL FDPS HNRNPF KRT19 LSM14A MGAT5B NIN OIP5 SMAD3 SPAG5 TTC19 TXLNA	29 interacting genes: BEND7 BIRC7 CALCOCO2 CEP70 CNOT1 EDC3 EIF4ENIF1 ENTR1 GOLGA2 IKZF1 KLC4 KRT40 KRTAP10-3 KRTAP10-8 NONO PNMA5 RBM14 RUNDC3A SIPA1L2 SRPK2 STAT1 TCF4 TLE5 TRIM27 TRIM37 U2AF2 VPS52 ZBTB8A ZNF24
Entrez ID		56478	1656
HPRD ID		10456	02638
Ensembl ID		ENSG00000184708	ENSG00000110367
Uniprot IDs		A0A024R1K0 Q9NRA8	B2R858 P26196
PDB IDs		5ANR 6F9W	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?
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