DDX6 and CNOT1

Number of citations of the paper that reports this interaction (PubMedID 24768540)
97

Data Source:
BioGRID (pull down)

		DDX6	CNOT1
Description		DEAD-box helicase 6	CCR4-NOT transcription complex subunit 1
Image
GO Annotations	Cellular Component	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Cadherin Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Viral RNA Genome Packaging Stem Cell Population Maintenance Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Neuron Differentiation Spermatid Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Multicellular Organism Development Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways		mRNA decay by 5' to 3' exoribonuclease	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs		D-tartaric acid
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)	Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		29 interacting genes: BEND7 BIRC7 CALCOCO2 CEP70 CNOT1 EDC3 EIF4ENIF1 ENTR1 GOLGA2 IKZF1 KLC4 KRT40 KRTAP10-3 KRTAP10-8 NONO PNMA5 RBM14 RUNDC3A SIPA1L2 SRPK2 STAT1 TCF4 TLE5 TRIM27 TRIM37 U2AF2 VPS52 ZBTB8A ZNF24	12 interacting genes: CNOT2 CNOT3 CNOT4 CNOT8 CNOT9 DDX6 NANOS3 PPARG RARA RXRA THRB TNRC6B
Entrez ID		1656	23019
HPRD ID		02638	11999
Ensembl ID		ENSG00000110367	ENSG00000125107
Uniprot IDs		B2R858 P26196	A5YKK6
PDB IDs		1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S	4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA
Enriched GO Terms of Interacting Partners?
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