PRPSAP1 and PRPS1

Number of citations of the paper that reports this interaction (PubMedID 9366267)
1

Data Source:
HPRD (in vivo, in vitro)

		PRPSAP1	PRPS1
Description		phosphoribosyl pyrophosphate synthetase associated protein 1	phosphoribosyl pyrophosphate synthetase 1
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GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Enzyme Inhibitor Activity Protein Binding Identical Protein Binding	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Catalytic Activity	5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Nucleoside Metabolic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Phosphorylation Urate Biosynthetic Process Hypoxanthine Biosynthetic Process
Pathways			5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Arts syndrome Phosphoribosylpyrophosphate synthetase I superactivity
GWAS		High-grade serous ovarian cancer ( 31469419) Urate levels ( 23263486)
Interacting Genes		5 interacting genes: DDX19B MAPK1 PLEKHF2 PRPS1 PRPS2	4 interacting genes: GORASP2 PRPSAP1 SPG21 SUMO4
Entrez ID		5635	5631
HPRD ID		03151	02413
Ensembl ID		ENSG00000161542	ENSG00000147224
Uniprot IDs		B4DP31 Q14558	B7ZB02 P60891
PDB IDs		2C4K	2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U
Enriched GO Terms of Interacting Partners?
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