PRPS1

Description		phosphoribosyl pyrophosphate synthetase 1
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GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Nucleoside Metabolic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Phosphorylation Urate Biosynthetic Process Hypoxanthine Biosynthetic Process
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Arts syndrome Phosphoribosylpyrophosphate synthetase I superactivity
GWAS
Interacting Genes		4 interacting genes: GORASP2 PRPSAP1 SPG21 SUMO4
Entrez ID		5631
HPRD ID		02413
Ensembl ID		ENSG00000147224
Uniprot IDs		B7ZB02 P60891
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U
Enriched GO Terms of Interacting Partners?
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