PRPS1 and SPG21

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		PRPS1	SPG21
Description		phosphoribosyl pyrophosphate synthetase 1	SPG21 abhydrolase domain containing, maspardin
Image			No pdb structure
GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol	Golgi Apparatus Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding CD4 Receptor Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Nucleoside Metabolic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Phosphorylation Urate Biosynthetic Process Hypoxanthine Biosynthetic Process	Antigen Receptor-mediated Signaling Pathway
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Arts syndrome Phosphoribosylpyrophosphate synthetase I superactivity	Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		4 interacting genes: GORASP2 PRPSAP1 SPG21 SUMO4	37 interacting genes: AGTRAP AKIRIN2 ARL6IP1 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 LMNA MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		5631	51324
HPRD ID		02413	10492
Ensembl ID		ENSG00000147224	ENSG00000090487
Uniprot IDs		B7ZB02 P60891	A0A024R5Y1 Q9NZD8
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U
Enriched GO Terms of Interacting Partners?
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