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MAPK3 and SOS1
Number of citations of the paper that reports this interaction (PubMedID
8621459
)
25
Data Source:
BioGRID
(enzymatic study, pull down)
MAPK3
SOS1
Description
mitogen-activated protein kinase 3
SOS Ras/Rac guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Nucleosome
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Molecular Function
Phosphotyrosine Residue Binding
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
DNA Binding
Guanyl-nucleotide Exchange Factor Activity
Ras Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
SH3 Domain Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Axon Guidance
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Platelet Activation
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Organic Substance
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Positive Regulation Of Metallopeptidase Activity
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
MAPK Cascade
B Cell Homeostasis
Hair Follicle Development
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of T Cell Proliferation
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Interleukin-15 signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Sulindac
Arsenic trioxide
Purvalanol
5-iodotubercidin
Ulixertinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Interacting Genes
171 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
BCL2
BCL3
BTBD10
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CEBPB
CPXM1
CREBBP
CREM
CRP
CUEDC2
DAPK1
DCC
DCP1A
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SREBF1
SREBF2
STAR
STAT3
STAT5A
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
55 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
ZAP70
Entrez ID
5595
6654
HPRD ID
03479
01681
Ensembl ID
ENSG00000102882
ENSG00000115904
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
G5E9C8
Q07889
PDB IDs
2ZOQ
4QTB
6GES
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
Enriched GO Terms of Interacting Partners
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