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MAPK3 and LYN
Number of citations of the paper that reports this interaction (PubMedID
11131153
)
5
Data Source:
HPRD
(in vivo)
MAPK3
LYN
Description
mitogen-activated protein kinase 3
LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Golgi Apparatus
Cytosol
Plasma Membrane
Postsynaptic Density
Mitochondrial Crista
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Mast Cell Granule
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Molecular Function
Phosphotyrosine Residue Binding
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
SH3 Domain Binding
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Ion Channel Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Phosphorylation-dependent Protein Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Axon Guidance
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Platelet Activation
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Organic Substance
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Positive Regulation Of Metallopeptidase Activity
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Blood Coagulation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Organic Cyclic Compound
Viral Process
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Platelet Activation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Proliferation
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Cytokine Secretion
Regulation Of Cytokine Secretion
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Sulindac
Arsenic trioxide
Purvalanol
5-iodotubercidin
Ulixertinib
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Granulocyte count (
27863252
)
Height (
18391951
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
27863252
)
Interacting Genes
171 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
BCL2
BCL3
BTBD10
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CEBPB
CPXM1
CREBBP
CREM
CRP
CUEDC2
DAPK1
DCC
DCP1A
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SREBF1
SREBF2
STAR
STAT3
STAT5A
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
117 interacting genes:
ACTB
ADAM15
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
5595
4067
HPRD ID
03479
01301
Ensembl ID
ENSG00000102882
ENSG00000254087
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
A8K379
P07948
Q6NUK7
PDB IDs
2ZOQ
4QTB
6GES
1W1F
1WA7
3A4O
5XY1
6NMW
Enriched GO Terms of Interacting Partners
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