PRKG2 and PTS

Number of citations of the paper that reports this interaction (PubMedID 10531334)
7

Data Source:
HPRD (in vitro, in vivo)

		PRKG2	PTS
Description		protein kinase cGMP-dependent 2	6-pyruvoyltetrahydropterin synthase
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GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Cofactor Metabolic Process Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Cofactor Metabolic Process
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Biopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood pressure (smoking interaction) ( 25189868) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	10 interacting genes: COIL DDX10 FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10
Entrez ID		5593	5805
HPRD ID		09034	11840
Ensembl ID		ENSG00000138669	ENSG00000150787
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	Q03393
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	3I2B
Enriched GO Terms of Interacting Partners?
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