PTS and PBRM1

Number of citations of the paper that reports this interaction (PubMedID 11591653)
41

Data Source:
HPRD (in vivo)

		PTS	PBRM1
Description		6-pyruvoyltetrahydropterin synthase	polybromo 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nuclear Chromosome Nucleoplasm RSC-type Complex SWI/SNF Superfamily-type Complex
	Molecular Function	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Identical Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Cofactor Metabolic Process	Mitotic Cell Cycle Nucleosome Disassembly Chromatin Remodeling Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation ATP-dependent Chromatin Remodeling
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs		Biopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) General cognitive ability ( 29844566) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Major mood disorders ( 20081856) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		10 interacting genes: COIL DDX10 FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10	9 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTS SMARCA4 ZDHHC17 ZNF512B
Entrez ID		5805	55193
HPRD ID		11840	07302
Ensembl ID		ENSG00000150787	ENSG00000163939
Uniprot IDs		Q03393	Q86U86
PDB IDs		3I2B	2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID
Enriched GO Terms of Interacting Partners?
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