PRKG2 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 12571245)
34

Data Source:
HPRD (in vitro, in vivo)

		PRKG2	LASP1
Description		protein kinase cGMP-dependent 2	LIM and SH3 protein 1
Image
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Cofactor Metabolic Process Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects
Drugs
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	40 interacting genes: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 COPS5 CRK DAZAP2 DNMT1 EHMT2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 RBPMS REL RHOXF2 SEPTIN3 SPRY2 STAT3 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 UHRF1 ZBTB9 ZC2HC1A ZYX
Entrez ID		5593	3927
HPRD ID		09034	04229
Ensembl ID		ENSG00000138669	ENSG00000002834
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	A0A024R1S8 B4DIC4 Q14847
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	3I35
Enriched GO Terms of Interacting Partners?
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