VPS11 and RAB7A

Number of citations of the paper that reports this interaction (PubMedID 25445562)
18

Data Source:
BioGRID (pull down)

		VPS11	RAB7A
Description		VPS11 core subunit of CORVET and HOPS complexes	RAB7A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane	Autophagosome Membrane Cell Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Endomembrane System Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein Binding, Bridging Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Regulation Of Protein Stability Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Autophagosome Assembly Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways			MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body mass index ( 29273807) Coronary artery disease ( 29212778)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		37 interacting genes: ALG9 BCAR1 BMI1 ECPAS EZR FUT1 GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MALL MARK3 MON1B MSN RAB7A RDX RILP RNF181 RNF26 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45 WNT1	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		55823	7879
HPRD ID		12258	03805
Ensembl ID		ENSG00000160695	ENSG00000075785
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	A0A158RFU6 P51149
PDB IDs			1T91 1YHN 3LAW 6IYB
Enriched GO Terms of Interacting Partners?
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