RAB7A and CHM

Number of citations of the paper that reports this interaction (PubMedID 9563513)
4

Data Source:
HPRD (in vitro)

		RAB7A	CHM
Description		RAB7A, member RAS oncogene family	CHM Rab escort protein
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cell Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Endomembrane System Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Protein Targeting To Membrane Small GTPase Mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Post-translational Protein Modification
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)
Interacting Genes		35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2	11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A
Entrez ID		7879	1121
HPRD ID		03805	02312
Ensembl ID		ENSG00000075785	ENSG00000188419
Uniprot IDs		A0A158RFU6 P51149	A8K545 B4DRL9 P24386
PDB IDs		1T91 1YHN 3LAW 6IYB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?