RAB7A and VPS39

Number of citations of the paper that reports this interaction (PubMedID 25445562)
18

Data Source:
BioGRID (pull down)

		RAB7A	VPS39
Description		RAB7A, member RAS oncogene family	VPS39 subunit of HOPS complex
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cell Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Endomembrane System Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome	Lysosomal Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2	8 interacting genes: HOOK1 NUSAP1 OIP5 RAB7A RILP RTF1 SNW1 STAT3
Entrez ID		7879	23339
HPRD ID		03805	10300
Ensembl ID		ENSG00000075785	ENSG00000166887
Uniprot IDs		A0A158RFU6 P51149	A0A024R9L9 Q96JC1
PDB IDs		1T91 1YHN 3LAW 6IYB
Enriched GO Terms of Interacting Partners?
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