PRKAR1B and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down)
HPRD (two hybrid, in vivo, in vitro)

		PRKAR1B	PRKAR1A
Description		protein kinase cAMP-dependent type I regulatory subunit beta	protein kinase cAMP-dependent type I regulatory subunit alpha
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Immunological Synapse Cytoplasm Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Ciliary Base Glutamatergic Synapse
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Renal Water Homeostasis Protein Phosphorylation Blood Coagulation Learning Or Memory CGMP-mediated Signaling Activation Of Protein Kinase A Activity Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP-dependent Protein Kinase Activity	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 27863252)	Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)
Interacting Genes		8 interacting genes: AKAP1 EGFR PPP1R9A PRKAR1A SMAD3 SMAD4 WNK1 WRN	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		5575	5573
HPRD ID		01485	01786
Ensembl ID		ENSG00000188191	ENSG00000108946
Uniprot IDs		P31321	B2R5T5 P10644
PDB IDs		4DIN 4F9K	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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