PRKAR1A and AKAP10

Number of citations of the paper that reports this interaction (PubMedID 9326583)
57

Data Source:
HPRD (two hybrid, in vitro)

		PRKAR1A	AKAP10
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	A-kinase anchoring protein 10
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Ciliary Base Glutamatergic Synapse	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding Protein Kinase A Binding
	Biological Process	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Signal Transduction Blood Coagulation Protein Localization
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs		Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)	Body mass index ( 29273807) Mean platelet volume ( 27863252) Platelet count ( 22139419 27863252) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WDCP WNK1 YWHAZ ZBED1	8 interacting genes: IKZF3 PDZK1 PRKAR1A PRKAR2A PRKAR2B RALA SASH1 SLC9A3R1
Entrez ID		5573	11216
HPRD ID		01786	05259
Ensembl ID		ENSG00000108946	ENSG00000108599
Uniprot IDs		B2R5T5 P10644	A0A0S2Z4Z7 E7EMD6 O43572
PDB IDs		5KJX 5KJY 5KJZ	3IM4 3TMH
Enriched GO Terms of Interacting Partners?
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