PRKAR1A and AKAP1

Number of citations of the paper that reports this interaction (PubMedID 9065479)
80

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PRKAR1A	AKAP1
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	A-kinase anchoring protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Ciliary Base Glutamatergic Synapse	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Blood Coagulation Regulation Of Protein Kinase A Signaling
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production
Drugs		Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)	Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WDCP WNK1 YWHAZ ZBED1	12 interacting genes: AMY1A APP CAV1 CFAP91 MYCBP PPP1CA PRKACA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21
Entrez ID		5573	8165
HPRD ID		01786	03905
Ensembl ID		ENSG00000108946	ENSG00000121057
Uniprot IDs		B2R5T5 P10644	A0A140VK05 B4DN86 Q92667
PDB IDs		5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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