PRKAR1B and WRN

Number of citations of the paper that reports this interaction (PubMedID 12067711)
4

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PRKAR1B	WRN
Description		protein kinase cAMP-dependent type I regulatory subunit beta	WRN RecQ like helicase
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck Neuron Projection
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding
	Biological Process	Renal Water Homeostasis Protein Phosphorylation Blood Coagulation Learning Or Memory CGMP-mediated Signaling Activation Of Protein Kinase A Activity Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP-dependent Protein Kinase Activity	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Brain Development Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organism Aging Replication Fork Processing DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process G-quadruplex DNA Unwinding Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Positive Regulation Of Strand Invasion Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases			Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 27863252)	Chronotype ( 30696823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Daytime sleep phenotypes ( 27126917) Exercise treadmill test traits ( 17903301) Fasting glucose change (long-term) ( 31263163) Intelligence (MTAG) ( 29326435) Lifespan ( 25918517) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Metabolite levels ( 23823483) Morning person ( 30696823)
Interacting Genes		8 interacting genes: AKAP1 EGFR PPP1R9A PRKAR1A SMAD3 SMAD4 WNK1 WRN	34 interacting genes: ATM ATRX BARD1 BLM BRCA1 CDKN2A FEN1 H2AX MDC1 MDM2 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBE2D2 UBXN8 VCP WRNIP1 XRCC5 XRCC6
Entrez ID		5575	7486
HPRD ID		01485	05212
Ensembl ID		ENSG00000188191	ENSG00000165392
Uniprot IDs		P31321	Q14191
PDB IDs		4DIN 4F9K	2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF
Enriched GO Terms of Interacting Partners?
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