ARFGAP1 and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ARFGAP1	RASIP1
Description		ADP ribosylation factor GTPase activating protein 1	Ras interacting protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytosol Postsynaptic Density Synapse	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Mean platelet volume ( 27863252) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		34 interacting genes: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		55738	54922
HPRD ID		06443	15214
Ensembl ID		ENSG00000101199	ENSG00000105538
Uniprot IDs		Q53F62 Q8N6T3	Q5U651 Q7L251 Q8IUR2
PDB IDs		3DWD 3O47	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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