RASIP1 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RASIP1	ARFGAP1
Description		Ras interacting protein 1	ADP ribosylation factor GTPase activating protein 1
Image
GO Annotations	Cellular Component	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Cytosol Postsynaptic Density Synapse
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity
Pathways			XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Mean platelet volume ( 27863252) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2	34 interacting genes: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23
Entrez ID		54922	55738
HPRD ID		15214	06443
Ensembl ID		ENSG00000105538	ENSG00000101199
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	Q53F62 Q8N6T3
PDB IDs		5KHO 5KHQ	3DWD 3O47
Enriched GO Terms of Interacting Partners?
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