PRKAG1 and PAICS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PRKAG1	PAICS
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Positive Regulation Of Protein Kinase Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Purine ribonucleoside monophosphate biosynthesis
Drugs		Acetylsalicylic acid	L-Aspartic Acid
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		16 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1	11 interacting genes: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1
Entrez ID		5571	10606
HPRD ID		04118	01401
Ensembl ID		ENSG00000181929	ENSG00000128050
Uniprot IDs		A0A024R125 P54619	P22234
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J	2H31
Enriched GO Terms of Interacting Partners?
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