PRKAG1 and AP1S3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PRKAG1	AP1S3
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	adaptor related protein complex 1 subunit sigma 3
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex	Golgi Membrane Lysosomal Membrane Cytosol Clathrin-coated Pit Membrane Coat Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding	Protein Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Positive Regulation Of Protein Kinase Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity	Protein Targeting Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		Acetylsalicylic acid
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Systolic blood pressure ( 27618447 30578418)	Airway wall thickness ( 25517131) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Initial alcohol sensitivity ( 30276832) Night sleep phenotypes ( 27126917) Sodium levels ( 29403010)
Interacting Genes		16 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1	2 interacting genes: AAGAB PRKAG1
Entrez ID		5571	130340
HPRD ID		04118	16495
Ensembl ID		ENSG00000181929	ENSG00000152056
Uniprot IDs		A0A024R125 P54619	Q96PC3
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J	4HMY 6CM9 6CRI 6D83 6D84 6DFF
Enriched GO Terms of Interacting Partners?
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