ZNF446 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 29426014)
4

Data Source:
BioGRID (two hybrid)

		ZNF446	UBE3A
Description		zinc finger protein 446	ubiquitin protein ligase E3A
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Space	Proteasome Complex Cell Nucleus Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Generic Transcription Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		24 interacting genes: ACTN2 DGCR6 DGCR6L FHL5 KRT40 KRTAP10-3 LZTS2 NOTCH2NLA PIN1 SUFU TRIM27 UBE3A ZKSCAN4 ZKSCAN7 ZNF165 ZNF232 ZNF24 ZNF263 ZNF496 ZSCAN16 ZSCAN21 ZSCAN22 ZSCAN32 ZSCAN9	121 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MCM6 MCM7 MDM1 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PSMD4 PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446
Entrez ID		55663	7337
HPRD ID		07934	03375
Ensembl ID		ENSG00000083838	ENSG00000114062
Uniprot IDs		Q8NDK2 Q9NWS9 Q9UFF2	Q05086 Q9H2G0
PDB IDs			1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV
Enriched GO Terms of Interacting Partners?
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