MCM10 and CDC45

Number of citations of the paper that reports this interaction (PubMedID 15232106)
123

Data Source:
HPRD (in vitro)

		MCM10	CDC45
Description		minichromosome maintenance 10 replication initiation factor	cell division cycle 45
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Proliferation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		35 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 RECQL4 TNIP1 TRIM37 YWHAE ZBTB43 ZBTB8A	23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TOPBP1 TRAPPC3 UBC
Entrez ID		55388	8318
HPRD ID		11297	09145
Ensembl ID		ENSG00000065328	ENSG00000093009
Uniprot IDs		Q7L590	O75419
PDB IDs			5DGO
Enriched GO Terms of Interacting Partners?
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