MCM10 and HOOK2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM10	HOOK2
Description		minichromosome maintenance 10 replication initiation factor	hook microtubule tethering protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex
	Molecular Function	DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Proliferation	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Monocyte count ( 27863252)
Interacting Genes		35 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 RECQL4 TNIP1 TRIM37 YWHAE ZBTB43 ZBTB8A	41 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 CCDC33 CWF19L2 DUSP13 EPS8 FAM107A HAUS1 HOOK1 HOOK3 IQCE ITSN2 KANSL1 KAT7 KIAA0408 KLK15 MCM10 PIMREG PSMF1 RALBP1 RIBC2 RITA1 RNF6 SMARCB1 SUV39H1 TPM3 TRMT1 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZNF250 ZNF638
Entrez ID		55388	29911
HPRD ID		11297	09698
Ensembl ID		ENSG00000065328	ENSG00000095066
Uniprot IDs		Q7L590	Q96ED9
PDB IDs
Enriched GO Terms of Interacting Partners?
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