MCM10 and MCM3

Number of citations of the paper that reports this interaction (PubMedID 15232106)
123

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MCM10	MCM3
Description		minichromosome maintenance 10 replication initiation factor	minichromosome maintenance complex component 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS
Interacting Genes		35 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 RECQL4 TNIP1 TRIM37 YWHAE ZBTB43 ZBTB8A	32 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 STAT1 SUPT16H SYF2 YWHAQ
Entrez ID		55388	4172
HPRD ID		11297	04072
Ensembl ID		ENSG00000065328	ENSG00000112118
Uniprot IDs		Q7L590	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs
Enriched GO Terms of Interacting Partners?
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