LGR4 and RSPO2

Number of citations of the paper that reports this interaction (PubMedID 24050775)
12

Data Source:
BioGRID (pull down, pull down, fluorescent resonance energy transfer)

		LGR4	RSPO2
Description		leucine rich repeat containing G protein-coupled receptor 4	R-spondin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cell Surface
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity	Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Osteoblast Differentiation Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Negative Regulation Of Cytokine Secretion Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)	Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		4 interacting genes: RSPO1 RSPO2 RSPO3 RSPO4	11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3
Entrez ID		55366	340419
HPRD ID		05978	17536
Ensembl ID		ENSG00000205213	ENSG00000147655
Uniprot IDs		Q59ER8 Q9BXB1	B3KVP3 Q6UXX9
PDB IDs		4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
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