RSPO2 and LGR5

Number of citations of the paper that reports this interaction (PubMedID 29769720)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RSPO2	LGR5
Description		R-spondin 2	leucine rich repeat containing G protein-coupled receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Trans-Golgi Network Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Hair Follicle Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Hormone-mediated Signaling Pathway Oocyte Differentiation Regulation Of Cell Proliferation Inner Ear Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Type 2 diabetes ( 22885922 18372903 29358691 30297969 20581827)
Interacting Genes		11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3	2 interacting genes: REEP5 RSPO2
Entrez ID		340419	8549
HPRD ID		17536	05979
Ensembl ID		ENSG00000147655	ENSG00000139292
Uniprot IDs		B3KVP3 Q6UXX9	A0A0A8K8C7 O75473
PDB IDs			4BSR 4BSS 4BST 4BSU 4KNG 4UFR 4UFS
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?