RSPO2 and ZNRF3

Number of citations of the paper that reports this interaction (PubMedID 29769720)
17

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RSPO2	ZNRF3
Description		R-spondin 2	zinc and ring finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Wnt Receptor Catabolic Process Limb Development Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 27618448 30487518) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Mean arterial pressure ( 29403010 27618448 30487518) Pancreatic cancer ( 29422604 25086665) Systolic blood pressure ( 27618448 30578418) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3	6 interacting genes: GFI1B HSPB1 RSPO1 RSPO2 RSPO3 UBE2N
Entrez ID		340419	84133
HPRD ID		17536	11737
Ensembl ID		ENSG00000147655	ENSG00000183579
Uniprot IDs		B3KVP3 Q6UXX9	A0A024R1J1 Q9ULT6
PDB IDs
Enriched GO Terms of Interacting Partners?
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