LGR4 and RSPO1

Number of citations of the paper that reports this interaction (PubMedID 24225776)
38

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		LGR4	RSPO1
Description		leucine rich repeat containing G protein-coupled receptor 4	R-spondin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Osteoblast Differentiation Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Negative Regulation Of Cytokine Secretion Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)	Axial length ( 24144296) Epithelial ovarian cancer ( 25581431) Eyebrow thickness ( 26926045) Intraocular pressure ( 29785010 31959993 30054594)
Interacting Genes		4 interacting genes: RSPO1 RSPO2 RSPO3 RSPO4	2 interacting genes: LGR4 ZNRF3
Entrez ID		55366	284654
HPRD ID		05978	08288
Ensembl ID		ENSG00000205213	ENSG00000169218
Uniprot IDs		Q59ER8 Q9BXB1	Q2MKA7
PDB IDs		4KT1 4QXE 4QXF	4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4CDK 4KNG 4KT1 4LI2 4QXF
Enriched GO Terms of Interacting Partners?
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