FBXW7 and SCGB3A1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		FBXW7	SCGB3A1
Description		F-box and WD repeat domain containing 7	secretoglobin family 3A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Extracellular Space Extracellular Exosome
	Molecular Function	Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	Cytokine Activity
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Signal Transduction Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Positive Regulation Of Myoblast Fusion
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		54 interacting genes: AHSG ANGPTL4 ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 EBNA1BP2 EXT1 EZH2 GATA2 GATA3 GLMN HEY1 HIPK2 HNRNPK IL24 JUN KLF10 KLF5 LINGO1 MAPK3 MCL1 MMS22L MYB MYC MYCN NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SHPRH SKP1 SOX9 SREBF1 STOML1 STYX SUMF2 TSC22D4 USP9X WDR97	9 interacting genes: AURKA BAG4 FBXW7 FGFR4 MARCO NOTCH3 TGFB1 TSG101 XRCC3
Entrez ID		55294	92304
HPRD ID		05888	05932
Ensembl ID		ENSG00000109670	ENSG00000161055
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q96QR1
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B
Enriched GO Terms of Interacting Partners?
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