FBXW7 and ANGPTL4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		FBXW7	ANGPTL4
Description		F-box and WD repeat domain containing 7	angiopoietin like 4
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Blood Microparticle
	Molecular Function	Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	Enzyme Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Angiogenesis Response To Hypoxia Lipid Metabolic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Apoptotic Process Protein Unfolding Positive Regulation Of Angiogenesis Negative Regulation Of Lipoprotein Lipase Activity Triglyceride Homeostasis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 28270201 24507774 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Phospholipid levels in large HDL ( 29084231) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 30275531 25961943 27036123) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		54 interacting genes: AHSG ANGPTL4 ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 EBNA1BP2 EXT1 EZH2 GATA2 GATA3 GLMN HEY1 HIPK2 HNRNPK IL24 JUN KLF10 KLF5 LINGO1 MAPK3 MCL1 MMS22L MYB MYC MYCN NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SHPRH SKP1 SOX9 SREBF1 STOML1 STYX SUMF2 TSC22D4 USP9X WDR97	9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1
Entrez ID		55294	51129
HPRD ID		05888	16173
Ensembl ID		ENSG00000109670	ENSG00000167772
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q9BY76
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B	6EUB 6U0A 6U1U 6U73
Enriched GO Terms of Interacting Partners?
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