FBXW7 and CCDC6

Number of citations of the paper that reports this interaction (PubMedID 25885523)
13

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		FBXW7	CCDC6
Description		F-box and WD repeat domain containing 7	coiled-coil domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cytosol Cytoskeleton
	Molecular Function	Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Cytoskeleton Organization Biological_process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Thyroid cancer
GWAS			Alopecia areata ( 25608926) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		54 interacting genes: AHSG ANGPTL4 ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 EBNA1BP2 EXT1 EZH2 GATA2 GATA3 GLMN HEY1 HIPK2 HNRNPK IL24 JUN KLF10 KLF5 LINGO1 MAPK3 MCL1 MMS22L MYB MYC MYCN NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SHPRH SKP1 SOX9 SREBF1 STOML1 STYX SUMF2 TSC22D4 USP9X WDR97	7 interacting genes: ATF2 CREB1 CSNK2A1 FBXW7 MAPK3 PPP4C UBE2I
Entrez ID		55294	8030
HPRD ID		05888	09064
Ensembl ID		ENSG00000109670	ENSG00000108091
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q05CP8 Q16204
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B
Enriched GO Terms of Interacting Partners?
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