MRGBP and TUBB

Number of citations of the paper that reports this interaction (PubMedID 12963728)
94

Data Source:
HPRD (in vitro)

		MRGBP	TUBB
Description		MRG domain binding protein	tubulin beta class I
Image
GO Annotations	Cellular Component	Nucleoplasm NuA4 Histone Acetyltransferase Complex	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone Acetylation Regulation Of Growth	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Synapse Organization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways		HATs acetylate histones	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Copper Depatuxizumab mafodotin Milataxel
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236)
Interacting Genes		21 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP10-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4	71 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		55257	203068
HPRD ID		16646	01852
Ensembl ID		ENSG00000101189	ENSG00000196230
Uniprot IDs		Q9NV56	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs		2N1D	3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVJ
Enriched GO Terms of Interacting Partners?
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