APPL2 and CRADD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		APPL2	CRADD
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	CASP2 and RIPK1 domain containing adaptor with death domain
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GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways			TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)	Alzheimer's disease (cognitive decline) ( 23535033) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		27 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RPL36 RUVBL2 SUV39H2 TINF2 TSC1	20 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN WIF1
Entrez ID		55198	8738
HPRD ID		06945	04584
Ensembl ID		ENSG00000136044	ENSG00000169372
Uniprot IDs		Q8NEU8	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		4H8S 5C5B	2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?
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