APPL2 and KMT2C

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		APPL2	KMT2C
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	lysine methyltransferase 2C
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GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transferase Activity, Transferring Acyl Groups Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation
Pathways			PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)
Interacting Genes		27 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RPL36 RUVBL2 SUV39H2 TINF2 TSC1	10 interacting genes: APPL2 DPY30 H3-4 H3C1 H3C14 JUN MAPK14 MTNR1B SMARCB1 TSC22D1
Entrez ID		55198	58508
HPRD ID		06945	06016
Ensembl ID		ENSG00000136044	ENSG00000055609
Uniprot IDs		Q8NEU8	Q8NEZ4
PDB IDs		4H8S 5C5B	2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC
Enriched GO Terms of Interacting Partners?
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