CRADD and KCTD9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CRADD	KCTD9
Description		CASP2 and RIPK1 domain containing adaptor with death domain	potassium channel tetramerization domain containing 9
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding	Protein Binding Identical Protein Binding Protein Self-association Cullin Family Protein Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Protein Ubiquitination Intracellular Signal Transduction Protein Homooligomerization
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		20 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN WIF1	28 interacting genes: AQP1 CARD9 CBX8 CCDC33 CRADD EHHADH FAM124B GEM GORASP2 KRT40 LONRF1 MAD2L2 MVP PNKD PPP1R16B PPP1R18 PSMA1 PSMB2 RBPMS SDCBP SKP1 SMARCB1 STX11 SYT6 TASOR2 TRIM27 TRIM32 TRIM42
Entrez ID		8738	54793
HPRD ID		04584	13772
Ensembl ID		ENSG00000169372	ENSG00000104756
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	Q7L273
PDB IDs		2O71 2OF5 3CRD	5BXH
Enriched GO Terms of Interacting Partners?
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