APPL2 and RAB5C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		APPL2	RAB5C
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	RAB5C, member RAS oncogene family
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GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Endomembrane System Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Intracellular Protein Transport Rab Protein Signal Transduction Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways			Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)	Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		27 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RPL36 RUVBL2 SUV39H2 TINF2 TSC1	19 interacting genes: APP APPL2 CCR10 DGKI EEA1 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 TBC1D15 TBC1D17
Entrez ID		55198	5878
HPRD ID		06945	04947
Ensembl ID		ENSG00000136044	ENSG00000108774
Uniprot IDs		Q8NEU8	A0A024R1U4 P51148
PDB IDs		4H8S 5C5B	4KYI
Enriched GO Terms of Interacting Partners?
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