RAB5C and RIN2

Number of citations of the paper that reports this interaction (PubMedID 12972505)
51

Data Source:
HPRD (two hybrid)

		RAB5C	RIN2
Description		RAB5C, member RAS oncogene family	Ras and Rab interactor 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Endomembrane System Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Cellular_component Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity GTPase Regulator Activity
	Biological Process	Intracellular Protein Transport Rab Protein Signal Transduction Neutrophil Degranulation Plasma Membrane To Endosome Transport	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)	Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 27863252) Smoking status (ever vs never smokers) ( 30643258) Verbal declarative memory ( 25648963) Weight ( 28552196)
Interacting Genes		19 interacting genes: APP APPL2 CCR10 DGKI EEA1 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 TBC1D15 TBC1D17	7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C
Entrez ID		5878	54453
HPRD ID		04947	15249
Ensembl ID		ENSG00000108774	ENSG00000132669
Uniprot IDs		A0A024R1U4 P51148	A1A4T0 Q8WYP3
PDB IDs		4KYI
Enriched GO Terms of Interacting Partners?
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