RNF43 and RSPO2

Number of citations of the paper that reports this interaction (PubMedID 29769720)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RNF43	RSPO2
Description		ring finger protein 43	R-spondin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cell Surface
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Pancreatic cancer ( 20686608) Prostate cancer ( 29892016) Stroke ( 29531354) Vitamin D levels ( 25208829)	Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		8 interacting genes: RSPO2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N	11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3
Entrez ID		54894	340419
HPRD ID		07896	17536
Ensembl ID		ENSG00000108375	ENSG00000147655
Uniprot IDs		J3KSE3 Q68DV7	B3KVP3 Q6UXX9
PDB IDs		4KNG
Enriched GO Terms of Interacting Partners?
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